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In terms of this, organic sulfur-containing amino acids, including Cys, are industrially important

NOX1 and DUOX2, prevalent along the GI tract, produce substantial ROS quantities, essential for an oxidative burst employed by innate immune cells to eliminate phagocytized pathogens (8, 9)

Amide bond Ester bond is relatively weaker than amide bond, it will be rapidly hydrolyzed by esterase enzyme Example Procaine Short acting local anesthetic Procainamide Long acting antiarrhythmic T1/2 = 40-84 second T1/2 = 2.5-4.5 hr Hydrolytic phase-I metabolism Examples of prodrugs activated by hydrolytic enzymes: Dipivefrine: is a di-tertbutylcarboxy ester of adrenaline

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