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A high-salt diet contributes to kidney stone risk, at least in part, because high sodium intake raises urine calcium concentration (Sakhaee, Maalouf 2012

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Moreover, because the clinical phenotype is restricted to skeletal muscle, the use of dermal fibroblasts represents an inherent limitation and may underestimate the severity of tissue-specific effects

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Under the prevailing nutritional conditions of dairy farms in the Colombian high tropics, it is likely that the negative energy balance (NEB) during the transition period forces cows to increase the use of amino acids for energy, diminishing the lysine and methionine pools, which are substrates for carnitine synthesis

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