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Such extranuclear mtDNA acts as a potent DAMP, capable of activating innate immune sensors including cGAS, TLR9, and the NOD, LRR and pyrin domain-containing protein 3 (NLRP3) inflammasome, thus triggering neuroinflammatory cascades [32,33,34]

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DOI: 10.3945/ajcn.112.042457

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For all neurological symptoms, the results were of greater magnitude for those reported to also have dispersant exposure than for those exposed to oil alone, perhaps indicative of recall bias