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About a year later, the University of Tokushima in Japan, in collaboration with Eisai, launched a Phase 3 trial called JETALS (NCT03548311) to confirm the results of the prior analyses

They are restorative, not explosive

They primarily absorb iron via DMT1 and rely on ceruloplasmin (CP) for its ferroxidase activity to oxidize Fe 2+ to Fe 3+ , thereby facilitating iron export and inhibiting lipid peroxidation (Jeong and David, 2003)