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Acknowledgements The authors thank the finantial support from FAPESP, Fundao de Amparo Pesquisa do Estado de So Paulo (grant number: 2025/28627-4), CAPES, Coordenao de Aperfeioamento de Pessoal de Nvel Superior (grant number 88887.991854/2024-00, recipient JMS), and CNPq, Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (grant number 308164/2022-9, recipient ACS)

Statistical analysis and reproducibility All statistical comparisons were made in GraphPad Prism 10.2.1 (GraphPad Software, San Diego, California USA, www.graphpad.com)

Detoxifies and fights oxidative stress

Evaluation of hemorrhage, sample size, and collateral damage for five hepatic biopsy methods in dogs

Here, we demonstrated the existence of succinylation modification on three K sites of GCLC, and their succinylation-simulating mutations nearly abolished the GCLC catalyzing activity, suggesting a pivotal role of succinylation modification in modulating GCLC enzymatic activity