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Around 1520% of patients with IBD demonstrate hypermethylation when treated with thiopurines, resulting in preferential metabolism of MP to methylmercaptopurine (MeMP)[54]

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Severe allergic reactions are rare, but medical advice should be sought if symptoms persist

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A better comprehension of the pathophysiological mechanisms underlying gastrointestinal conditions will lead to new non-drug and medication-based treatments

doi: 10.3389/fonc.2022.775649 Received 14 September 2021 Accepted 27 January 2022 Published 17 February 2022 Volume 12 - 2022 Edited by Bilian Jin, Dalian Medical University, China Reviewed by Tiziana Schioppa, University of Brescia, Italy