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The xenograft mice were treated with 5-FU alone, RSL3 alone, or a combination of 5-FU and RSL3 ( Figure 5E )

Kasi PM, Fehringer G, Taniguchi H, Starling N, Nakamura Y, Kotani D, Powles T, Li BT, Pusztai L, Aushev VN, Kalashnikova E, Sharma S, Malhotra M, Demko ZP, Aleshin A, Rodriguez A, Billings PR, Grothey A, Taieb J, Cunningham D, Yoshino T, Kopetz S

Human cells, in contrast, upregulate several mitochondrial electron transport chain subunit components during short-term hypoxia exposure, consistent with increased mitochondrial branch length after 1 h, but overall changes in mitochondrial respiration in human cells following hypoxia/reoxygenation are milder than those in seal cells and are accompanied by higher ECAR, suggesting that human but not seal cells rely on glycolysis to support continued respiration during hypoxia

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Cheung, V., Yuen, V

Dysregulation of this pathway could lead to neuronal stress and death (119)