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Several groups benefit most from B12 injections based on documented risk of deficiency: People with pernicious anemia or lacking intrinsic factor Vegans and vegetarians with limited dietary B12 Older adults, who absorb B12 less efficiently Patients after gastric or intestinal surgery Those with Crohns disease, celiac disease, or other malabsorption conditions Long-term users of metformin or acid-reducing medications Do B12 Shots Actually Boost Energy If My Levels Are Normal