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Once absorbed, vitamin B12 is highly bound to transcobalamin II, a specific B-globulin carrier protein and is distributed and stored primarily in the liver as coenzyme B12

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doi.org/10.1017/S0007114507764747 Calder PC

A randomised Phase 2 study suggested that treatment with afatinib does not confer therapeutic benefits, and resulted in even more frequent adverse events than the investigators choice of treatment for HER2 + BCBM patients