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Other Possible Drug Combinations Cisplatin is also used in combination with natural compounds like osthole in lung cancer cell lines (Xu, Zhang et al., 2013), honey bee venom in ovarian cancer cells (Alizadehnohi, Nabiuni, Nazari, Safaeinejad, and Irian, 2012), anvirzel in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines (Apostolou, Toloudi et al., 2013), bevacizumab in non-small cell lung cancer-mediated malignant pleural effusion (Du, Li et al., 2013), vinblastine and bleomycin in metastatic granulosa cell tumor of the ovary (Colombo, Sessa et al., 1986), methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract (Dexeus, Logothetis et al., 1991)

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Following AMPK activation, cordycepin further promotes mitochondrial autophagy and functional recovery, accelerating the clearance of damaged mitochondria and reducing reactive oxygen species accumulation

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