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To address this, the FDA updated its guidelines in 2016, allowing metformin use in patients with mild to moderate kidney impairment but advising against its use in those with severe kidney disease (eGFR below 30 mL/min/1.73 m)

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doi: 10.1186/1477-7819-12-164 126 NguyenTTLianSUngTTXiaYHanJYDo JungY

Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats