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In detail, the NTP determined there was strong, though not sufficient, evidence for persistent NSW (long-term, frequent, or beginning at an early age), supported by mechanistic data on circadian disruption, while IARC classified NSW as probably carcinogenic to humans (Group 2 A) based on limited human and sufficient animal evidence 276,277

Jain S, Su YH, Su YP, McCloud S, Xue R, Lee TJ, Lin SC, Lin SY, Song W, Steffen JD, Hu CT

And I'm like, I can't do this anymore

What would that allow in your life

These data suggest that ARR2 directly interacts with SORLA, but with a lower affinity compared to VPS26

Rochette L, Gudjoncik A, Guenancia C, Zeller M, Cottin Y, Vergely C