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For instance, a Bhas 42 cell (mouse fibroblast-derived) transformation assay can be used to show that the aerosols of cMRTPs cause significantly less cell transformation than cigarette smoke [49]

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A single Black and Mild's tobacco can contain roughly 100200 mg of nicotine, figures that trace back to a 2007 Baltimore City Health Department analysis and are still widely cited today

Figure 1 Trends in dual use by tobacco/nicotine product types between 2007 to 2018 in South Africa FM Cigarettes and SLT The prevalence of the dual use of FM cigarettes and SLT significantly increased from 0.5% (95% CI: 0.31.0) in 2007 to 0.7% (95% CI: 0.31.3) in 2010 and remained stable at between 0.4% and 0.5% in 2011 and 2017, respectively

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