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401 A meta-analysis of five randomized controlled trials with a total of more than 11,000 participants found colchicine reduced the risk of major thromboembolic cardiovascular events in patients with coronary artery disease, but had no effect on cardiovascular mortality

On the other hand, getting the proper amount of vitamin B12 into the body can help in lifting the mood, which can lead to lesser feelings of depression, and some research suggests that antidepressants can work better when a patient can also receive added vitamin B12

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