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Small lipophilic molecules can still diffuse across

Mgarbane B, Delahaye A, Goldgran-Toldano D, Baud FJ

That is why we use B12 as a supporting piece of a full medical weight loss program, not a standalone fix

Kang T, Miao Z, Liu S, Ke B

We also used homozygous APOE3 and APOE4 mice, which do not reflect the full spectrum of APOE allele combinations in humans (Hana Saddiki et al., 2020)