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K., Abolghasemi, S., Frashidi, M., Ebrahimi, S., Gharei, F., Razmkhah, Z., Tavousi, N., Mahmoudvand, B., Faani, M., Karimi, N., Abdi, A., Soleimanzadeh, M., Youshanlui, M

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Tuft cells are chemosensory cells detect microbial or parasitic signals and secrete interleukin-25 (IL-25), which activates group 2 innate lymphoid cells (ILC2s) ( Clostridioides difficile infection (CDI) colitis models, IL-25 expression is suppressed, and IL-25 supplementation restores eosinophil numbers and reduces mucosal injurydespite no changes in bacterial burden or toxin levels ( Furthermore, eosinophils can secrete anti-inflammatory and pro-resolving mediatorsfor example, they are a source of specialized pro-resolving mediators (SPMs) like maresins and protectins ( In summary, the role of eosinophils in the intestine has expanded from a narrow focus on parasite defense to a broader appreciation of their part in immune modulation, host-microbiome interactions, and tissue homeostasis