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Although xCT expression is confined to the plasma membrane in normal tissues (36,39), it is upregulated in certain types of cancer, such as colorectal cancer, malignant glioma and non-small cell lung cancer, which increases cystine uptake (4042)

Molecules 25 , 5591 (2020)

The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4

Among approved drugs, tirzepatide has produced the largest average weight loss in head-to-head research

6PGD promotes the formation of distant metastatic subclones in pancreatic ductal adenocarcinoma (PDAC) by regulating epigenetic reprogramming

Additionally, a high A42/A40 ratio is associated with the formation of amyloid plaques found in familial AD patients 12,32