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These variants subsequently cause a RAS-protein gain of function associated with enhanced GTP activity, since GTPase-activating proteins (GAPs) are unable to bind KRAS, thus increasing the intrinsic GTPase activity of KRAS (Johnson et al

Senol, A., Yucelten, A

10.1111/cns.13548 CNS Neurosci

In Alzheimers disease models of Drosophila expressing wild-type human amyloid-beta 42, kaempferol alleviates symptoms by reducing oxidative stress in the brain (Han et al., 2019)