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This evidence was strengthened by studies in vivo in which manipulation of calpastatin levels, an endogenous calpain inhibitor, led to modulation of the neurological phenotype seen in a SCA3 mouse model, as well as of mutant ATXN3 aggregation and neurodegeneration, consistent with a role for calpain activation in pathogenesis [50, 52]

Anthocyanidins and cyanidin-3-glucoside (C3G) found in bilberry have been shown in preclinical studies to protect eye health

Period Support Capsules Ingredients: Ginger root powder, ground Ceylon cinnamon, chamomile flower extract, hydroxypropyl methylcellulose (capsule shell), ladys mantle extract, Chinese angelica extract, silverweed root extract, black cohosh root extract, shepherds purse extract, common yarrow extract Average nutritional values 1 : 1 The nutrient content of the raw materials is subject to natural variations

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doi: 10.3390/molecules25010182 9

Serine and its derivative glycine (via SHMT1/2) fuel nucleotide, protein, and lipid biosynthesis, antioxidant defenses (including glutathione and NADPH production), and one-carbon metabolism for methylation reactions [14]