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Species-specific differences in receptor distribution further complicate extrapolation from preclinical models to humans, and the presence of these receptors in peripheral tissues raises concerns regarding off-target uptake (Zhang et al., 2020)

Further laboratory research involves examination of its effects on mitochondrial membranes, ATP synthesis and bioenergetics of cells, with further application in age-related physiology, muscle function, cardiovascular and neurodegenerative research

However, it is always advisable to conduct a patch test before full application

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It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)

But as you age, the signaling molecules that coordinate this repair process decline