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Given that the phenotype is highly variable, it is likely that residual TPK1 activity and/or other cellular kinases (albeit at a lower extent and favored by the mass action of high thiamine doses) may also phosphorylate thiamine, thereby partly circumventing the metabolic block

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They are not associated with melanophage accumulation or a fibrotic reaction

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10.1016/j.pbb.2021.173205 88

The development of individualized rehabilitation exercise strategies for patients with coexisting COPD and sarcopenia may be beneficial for their functional maintenance