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First, S-nitrosylation of Hsp70/Hsp90 organizing protein (Hop/Stip-1) reduces its expression and inhibits its association with CFTR in the endoplasmic reticulum, facilitating F508del-CFTR maturation (Marozkina et al., 2010)

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This mechanism also means Benzonatate is less likely to cause drowsiness, making it a preferred option for many patients